Unfortunately neither of those conditions are particularly well understood.It is true that there are believed to be genetic influences in both of them, but there are also many other factors that researchers are looking at. Exactly how much genetic influence is not clear at all, and a genetic history certainly doesn't mean that children will develop them.On the positive side, there is no evidence whatsoever that autism is influenced by vaccinations - something which has become internet folklore and has been disproven by recent large-scale scientific studies. Also early diagnosis of autism is becoming better, and autistic children who get early intervention therapies are showing great improvements.Schizophrenia normally doesn't develop until adulthood. Its cause is pretty much a mystery but research is concentrating on brain development. It certainly seems to have a genetic component, but research suggests that its onset can be signficantly affected by environmental factors like psychological stress. With one known case in your family of each (and on different sides), and yourselves being presumably healthy, it doesn't sound like the genetic risk is very significant for any children you might have. Remember also that these two conditions, while both affecting the brain, are unrelated so the risk is not increased by having one of each in the family.