You could pop off some keys, but you have to be careful not to use too much force. I've had to do this many times in the past with older keyboards. With today's keyboards, I'm not sure how well it works. Keyboards have gotten to the point of being so cheap these days, you can replace it at the cost of $ and driving instead of pulling keys apart and taking time to clean it, and potentially find you can't replace the key.Might try this site (found through google) http://www.mahalo.com/How_to_clean_a_computer_keyboard